carnosol inhibits inflammasome activation by directly

Identification of ethyl pyruvate as a NLRP3 inflammasome

Mar 15 2018Ethyl pyruvate inhibits NLRP3 agonists-induced inflammasome activation in mouse macrophages a Peritoneal mouse macrophages were primed with ultra-pure LPS (1 μg/ml) for 3 h in the presence or the absence of EP (1 or 5 mM) and then stimulated with ATP (5 mM) for 30 min The pro-caspase1 cleavage of caspase-1 and Pro-IL-1β IL-1β and the release of HMGB1 in supernatants

Frontiers

Inflammation is a crucial component of various stress-induced responses that contributes to the pathogenesis of major depressive disorder (MDD) Depressive-like behavior (DLB) is characterized by decreased mobility and depressive behavior that occurs in systemic infection induced by Lipopolysaccharide (LPS) in experimental animals and is considered as a model of exacerbation of

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Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases View PDF In Cell Death Disease on 20 April 2020 by Shi W Xu G et al Modulation of NLRP3 Inflammasome through Formyl Peptide Receptor 1 (Fpr-1) Pathway as a New Therapeutic Target in Bronchiolitis Obliterans Syndrome

13

Jan 22 2020These results showed that the NLRP3 inflammasome is directly activated when exposed to H 2 O 2 which may influence the level IL-1β secretion in HUVECs However pretreatment with 13- suppressed NLRP3 inflammasome activation and downregulated the level of IL-1β 13- inhibits the NLRP3 inflammasome by enhancing autophagy in HUVECs

Dopamine Controls Systemic Inflammation through Inhibition

The dysregulation of NLRP3 inflammasome contributes to many inflammation-associated diseases Yan et al now find that dopamine and DRD1 signaling function as an endogenous restrictor of NLRP3 inflammasome activation and can control both neuroinflammation and periphery inflammation via promoting NLRP3 ubiquitination and degradation suggesting that DRD1 might be a new target for

miR

Apr 01 2019In conclusion the present study shows that miR-16 directly regulates the activation of NLRP3 inflammasome by TLR4/ NF-κB pathway in response to LPS stimulation Further it reveals that overexpression of this miRNA inhibits the inflammatory response of LPS-induced lung injury

Recent advances in the NEK7

Sep 01 2020In particular ALK does not contact NLRP3-NEK7 complex directly but mediates lipid peroxidation causing the production of inflammatory mediator 4-hydroxynonenal (4-HNE) which is responsible for the NLRP3 inflammasome activation As mentioned above ROS is an important signal for NEK7-licensed NLRP3 inflammasome activation as well

Silybin inhibits NLRP3 inflammasome assembly through the

In our study we found that silybin inhibited endoplasmic reticulum stress and NLRP3 inflammasome activation in the livers of HFD‐fed mice and in cultured hepatocytes Phosphorylation of inositol‐requiring enzyme (IRE) 1α and eIF2α expression of thioredoxin‐interacting protein and cleaved caspase‐1 and release of IL‐1β were

Caspase

To investigate whether caspase-6 is also involved in NLRP3 inflammasome activation we treated LPS-primed wild-type (WT) and caspase-6-deficient (Casp6 –/–) bone marrow-derived macrophages (BMDMs) with ATP or nigericin BMDMs from both genotypes showed similar cleavage of caspase-1 production of the inflammasome effector cytokines IL-1β and IL-18 and pyroptosis suggesting that caspase-6

Fucoidan Inhibits NLRP3 Inflammasome Activation by

NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation contributes to the progression of atherosclerosis and autophagy inhibits inflammasome activation by targeting macrophages We investigated whether fucoidan a marine sulfated polysaccharide derived from brown seaweeds could reduce NLRP3 inflammasome activation by enhancing sequestosome 1

Melatonin alleviates acute lung injury through inhibiting

During ALI the NLRP3 inflammasome is significantly activated with a large amount of IL‐1β and the activated caspase‐1 occurring in the lung Melatonin inhibits the activation of the NLRP3 inflammasome by both suppressing the release of extracellular histones and directly blocking histone‐induced NLRP3 inflammasome activation

Fucoidan Inhibits NLRP3 Inflammasome Activation by

NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation contributes to the progression of atherosclerosis and autophagy inhibits inflammasome activation by targeting macrophages We investigated whether fucoidan a marine sulfated polysaccharide derived from brown seaweeds could reduce NLRP3 inflammasome activation by enhancing sequestosome 1

Easier Detection of Inflammasome Activation

The addition of MG-132 inhibits non-specific proteasome activity enabling direct detection of caspase-1 activity Since the assay detects only catalytically active caspase-1 you can determine the precise time course of inflammasome activation and deactivation

Cyclosporin

Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases Endocrine disorders after heart transplantation: national cohort study Efficacy and safety of rituximab in the treatment of membranous nephropathy: A systematic review and meta-analysis

NLRP3 inflammasome inhibition attenuates subacute

Feb 28 2020In conclusion this study demonstrates that NLRP3 inflammasome activation contributes to AA-induced neurotoxicity whereas the specific NLRP3 inflammasome blocker MCC950 or NLRP3 knockout mice could effectively protect against AA poisoning by inhibiting neuroinflammation and up-regulating Nrf2 antioxidant pathway

Identification of ethyl pyruvate as a NLRP3 inflammasome

Mar 15 2018Ethyl pyruvate inhibits NLRP3 agonists-induced inflammasome activation in mouse macrophages a Peritoneal mouse macrophages were primed with ultra-pure LPS (1 μg/ml) for 3 h in the presence or the absence of EP (1 or 5 mM) and then stimulated with ATP (5 mM) for 30 min The pro-caspase1 cleavage of caspase-1 and Pro-IL-1β IL-1β and the release of HMGB1 in supernatants

Caspase

To investigate whether caspase-6 is also involved in NLRP3 inflammasome activation we treated LPS-primed wild-type (WT) and caspase-6-deficient (Casp6 –/–) bone marrow-derived macrophages (BMDMs) with ATP or nigericin BMDMs from both genotypes showed similar cleavage of caspase-1 production of the inflammasome effector cytokines IL-1β and IL-18 and pyroptosis suggesting that caspase-6

Inflammasome activation and assembly at a glance

Inflammasomes are multimeric protein complexes that typically comprise a sensor an adaptor and the zymogen procaspase-1 An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs) The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage which further induces

Mechanism and Regulation of NLRP3 Inflammasome Activation

The NLRP3 inflammasome is thought to sense the disturbance of cellular homeostasis rather than directly recognizing a common motif present in its activators and multiple cellular signals have been proposed to trigger its activation including K + efflux Ca 2+ signaling mitochondrial dysfunction and lysosomal rupture

Dopamine Controls Systemic Inflammation through Inhibition

The dysregulation of NLRP3 inflammasome contributes to many inflammation-associated diseases Yan et al now find that dopamine and DRD1 signaling function as an endogenous restrictor of NLRP3 inflammasome activation and can control both neuroinflammation and periphery inflammation via promoting NLRP3 ubiquitination and degradation suggesting that DRD1 might be a new target for

The Yersinia pestis Effector YopM Inhibits Pyrin

Dec 02 2016The picture that emerges is consistent with the hypothesis that YopM is an inhibitor of the Pyrin inflammasome triggered by YopE whereas YopK inhibits NLRP3/NLRC4 activation triggered by the presence of the T3SS needle/translocon This emphasizes a new complexity in the host inflammasome activation triggered by the Y pestis T3SS

Critical role for calcium mobilization in activation of

Jul 10 2012The NLRP3 (nucleotide-binding domain leucine-rich-repeat-containing family pyrin domain-containing 3) inflammasome mediates production of inflammatory mediators such as IL-1β and IL-18 and as such is implicated in a variety of inflammatory processes including infection sepsis autoinflammatory diseases and metabolic diseases The proximal steps in NLRP3 inflammasome activation

Fucoidan Inhibits NLRP3 Inflammasome Activation by

NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation contributes to the progression of atherosclerosis and autophagy inhibits inflammasome activation by targeting macrophages We investigated whether fucoidan a marine sulfated polysaccharide derived from brown seaweeds could reduce NLRP3 inflammasome activation by enhancing sequestosome 1

Silybin inhibits NLRP3 inflammasome assembly through the

THE JOURNAL † RESEARCH † Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease Bangling Zhang * 1 Dan Xu † 1 Linlin She ‡ Zixia Wang ‡ Na Yang * Runbin Sun * Yirui Zhang * Caixia Yan * Qingli Wei * Jiye Aa * Baolin Liu ‡ Guangji Wang * 2 and Yuan Xie* 3 *Key Laboratory of Drug Metabolism and